1 definition by Thorsbanjo

Top Definition
1. The trade of goods between early Europe and the Americas that resulted in large cultural and material gains for European countries widespread disease in the unprepared American native tribes.

2. When a long term partner takes advantage of the other by not telling them about their herpes.
I think Chris pulled a Columbian Exchange on me last night
by Thorsbanjo September 12, 2011

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