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1 definition by ThomasGRogan

A less serious name for anal and/or colon cancer
Dr. Gupta: You have butthole cancer.

Mr. Larrity: What are you talking about?

Dr. Gupta: It affects 99% of CEOs and 100% of politicians at some point in their lives. We will have to remove your butthole before it spreads.
by ThomasGRogan November 26, 2009