1.) The response someone makes when one tells a retarded joke, says something stupid, or does something rude, annoying, obnoxious, or gross.
2.) A comment one makes on a bad or ugly facebook photo.
3.) What to say to stalkers before they kill/rape you.
Lou: "I KNOW A SONG THAT GETS ON EVERYBODY'S NERVES, EVERYBODY'S NEVERS, EVERY-"
Stan: "Ew, die."