Based on the seminal psychological experiments by the eponymous scientist, the phrase has come to indicate a situation in which a straight man, traditionally equipped with a thorn-like tongue stud, provides such explosively exciting cunnilingus to a lesbian that she questions and/or reconsiders her sexual orientation.
Phil: Yo Tawd, did you end up scoring with that short-haired hipster chick last night? We all thought she was a lesbian!
Tawd: Turns out you guys were right, but after a good 'ol Thorndike Confused Cat last night, she stuck around for pancakes and buttsex this morning!
Phil: Dude, the final frontier?! Awesome!
Tawd: Yep. Pretty awesome.