A derogatory term used to represent fat/homely/fugly
The term twinkie was origionally derived from the phrase, "fat chicks smell like twinkies".
It was once thought that a women who ate their own weight in twinkies would eventually smell like twinkies.
"Dude, dont look now, but that twinkie in the red dress is checking you out!"
"Aww dude... She looks like the kool-aid man...with cankles