The same as the term "Getting your diaper in a bunch" or "Panties in a wod"
Getting upset when there's no reason to be.
Getting all riled up.
President: “There's something about August going into September -- where everybody in Washington gets all wee-wee'd up,”
Translation: People are not really upset over the Health Care Debate, it's the change in season that has got everyone all riled up.
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