FTN is an acronym that stands for "Fuck That Noise". It is often used as punctuation at the end of a rant or statement expressing distaste. It also can be used as a general statement/reply.
"Dude, i got a 45 on my history test even though i studied for like eighteen hours last night, FTN!"
person 1: "Did you hear they finally fired Larry?"
person 2: "What!? FTN!"
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