(29 letters; an estimation of something as worthless) is the longest word in the first edition of the Oxford English Dictionary. The OED2 shows a use of this word in a 1741 letter by William Shenstone (1714-1763), a British poet and essayist. It has been used by Sir Walter Scott and Senators Robert Byrd and Daniel Patrick Moynihan. It was used by Senator Jesse Helms in 1999 during the debate on the Comprehensive Test Ban Treaty Randolph V. Cinco. It also appeared on March 14, 1996, in "Zippy," a comic strip distributed by King Features Syndicate:
Do you think I may be too quick to find fault with things and people, Zippy?
Th' 'floccinaucinihilipilification' process.
Floccinaucinihilipilification!! It means 'the estimation of something as valueless'!
You've been randomly reading th' dictionary, haven't you?
Yes. That and my natural tendency toward antifloccinaucinihilipilification!!