Made popular in a video review of Newmen #1 by Linkara.
It refers to certain type of bad facial feature in comic books, where Linkara first noticed it in Young Blood's #1.
The eyes on characters are either non-existant or just really poorly drawn in. Young Blood's Disease afflicted millions during the Dark Age of Comics, and even today cases have been known to pop up.
This comic book sucks! Who the hell drew the faces for these characters? They've all got Young Blood's Disease!