1. Short for Panayioti which in greek translate to "Holy Mother of God"
2. Slang for a Greek man, either overly handsome or overly smooth, or both.
3. Short for Panorama, a type of view or picture with an abnormally wide view
"Let me take a look at that Pano picture"
"Keep my wife or sheep away from that Greek, he is definitely a Pano!"