The most well-known catchphrase on SANFORD & SON. Whenever Fred Sanford heard something particularly distressing, he always staggered around clutching his chest and shouted to his deceased wife, "This is the big one! I'm comin' Elizabeth!" This particularly applies to whenever you hear some really awful, distressing news, bad enough to make you think you were having a heart attack.
YOUR BOSS: I'm afraid I have some bad news: you won't be getting your bonus, I need you to work overtime next week, and your car's just been impounded.
YOU: Oh, my God! This is the big one! I'm coming, Elizabeth!