The most well-known catchphrase on SANFORD & SON. Whenever Fred Sanford heard something particularly distressing, he always staggered around clutching his chest and shouted to his deceased wife, "This is the big one! I'm comin' Elizabeth!" This particularly applies to whenever you hear some really awful, distressing news, bad enough to make you think you were having a heart attack.
YOUR BOSS: I'm afraid I have some bad news: you won't be getting your bonus, I need you to work overtime next week, and your car's just been impounded.
YOU: Oh, my God! This is the big one! I'm coming, Elizabeth!
Perhaps the most famous line from Cpt. Jean-Luc Picard in the STAR TREK: TNG episode "Datalore". Picard tells Wesley to shut up after he tries to warn the crew that they were actually talking to Lore, Data's evil twin. This also works when someone won't stop whining about something.
OTHER PERSON: You know, I wish you'd listen to me once in a while, because I happen to know...
YOU: Shut up, Wesley!