A relationship between a man and his twitter account that borders on unhealthy, whereby said man tweets constantly but seems unable to spare his girlfriend one text, despite being able to both tweet and text on his mobile phone.
Named after the infamous dumping of John Mayer by Jennifer Aniston because he tweeted too much but did not seem to be able to drop her a text.
My boyfriend just got a twitter account last weekend and now he's suffering from the John-Jen Syndrome! FML
Man did you hear about how Alex got dumped because he was doing a John-Jen Syndrome on his girl?