Someone who is painfully irritating and doesn't even realise this and who tries to be a nice guy but doesn't understand how to socialize properly resulting on him getting rejected and usually isolated, also James's tend to have anger issues resulting in them being mocked after having an outburst.
James can also be used to describe when you are rejected from social groups or events.
George: I didn't get invited to that party on the weekend and Angel won't talk to me after I tired to touch her ass.
Tom: Dude you totally becoming a James!
George: SHUT THE FUCK UP I'M NOT A JAMES!