1 definition by Most_ill

Top Definition
1. Greeting to someone. A way of saying "hey what's up?" origniated in Detroit.

2. Can be used as a term of aggression to entice someone into a fight or altercation; Bring it on...
1. Guy sees his buddy and greets him with " What up Doe?"

2. Guy 1 walks into a bar with the mean mug, staring at guy 2. Guy 2 throws up both hands and says "What up Doe!?"
by Most_ill December 04, 2009

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