most men prefer the gender pronoun "he", "him" and "his", most women prefer the gender pronoun "she", "her" and "hers"
however some people prefer different pronouns than normal because their gender doesn't fit into "man" or "woman" and a transgender person might prefer a pronoun that is not the one they were assigned at birth.
it is considered polite to, instead of asking "are you a man or a woman?" to someone who's gender you cannot determine immediately, ask "what's your PGP?" An explanation is sometimes necessary