1) Skipping certain parts of a musical composition, esp. long intros, gay bridges, or pretentious outros.
2) Skipping the crappy songs on an album/playlist to get to the better ones.
*Two guys listening to My Curse by Killswitch Engage*
Guy One: *Starts song*
Guy Two: Skip the fluff, please.
Guy One: What? I love Killswitch.
Guy Two: Ive heard this song way to many times, and Im really starting to get tired of the intro. Skip it, you fanboy whore.