Appundicitis is a cancerous disease responsible for thousands of deaths worldwide every year. When a person makes too many puns and stops being funny altogether, there is a good chance that they have contracted appundicitis. There is little to no chance of survival or recovery.
Daughter: "Mommy, is daddy going to be okay?"
Mother: "I'm sorry, sweetie, but he's got appundicitis. Even if he were to cover, he wouldn't be the same person he was before. He'd be less funny. We have to put him down"