Too express extreme disapointment, anger, suprise, rage or disapproval in a situation or thing. This phrase is best used when you feel damnation from God is not enough (God Damn It), and the only appropriate action is for God to 'fuck' the condemned in a manner suiting the prefered connotation of the word 'fuck.' (E.X. To fornicate, to treat in a harsh manner, distort, ect.)
GOD FUCK that stupid whore
Jane lost the Dog? GOD FUCK!