A state of being very high energy and restless combined with disorientation as a result of consuming meth or exctacy pills containing amphetamines. Accompanied with dilated pupils and sometimes the desire to get punched in the face.
A: Shit, look at his eyes!! He's hella twacked out.
B: I'm so twacked out, I bet if you punch me as hard as you can in the face it won't hurt.