A man or woman who feels that he or she was born into the wrong gender. The man or woman most likely has the personality of the opposite gender, and feel they cannot relate to their own gender. Also, someone who has undergone surgery to become the opposite gender they yearned to be.
I. I've always had a desire to be a man; I am a transsexual.
II. David used to be Delilah- he is a transsexual.