A fanterm used to describe the yaoi(boyxboy) pairing of Antonio Fernandez Carriedo and Lovino Vargas from the anime series Axis Powers Hetalia. In the series, countries are represented as "human" nations, as Antonio represents the Kingdom of Spain and Lovino represents Italian Republic, Southern Italy or just Romano.
The "Spa" part stands for Spain and the "mano" part for Romano.
some Random guy: " OMG, Spamano Kawaii DESU!!"
some Random girl: "This couple is as weird and tsundere as Spamano!"