1. Is a pandemic that affects not only men but also women. It is a debilitating condition that is caused by your significant other destroying you from the inside out day by day. Until you lack the fortidude to carry on. Sadly once you are destroyed from the inside out, the main side effect of Ball disease is Marriage.
2. When you are unable to muster up the confidence to go speak to some one of the opposite sex.
Allen: I asked her to Marry me!
Jeff: WTF is wrong with you? Sounds like you have a pretty bad case of Ball Disease...
David: Man you should go talk to her, shes been giving you the fuck me eyes all night.
Tony: Well... I would, but...
David: Whats that? Oh thats right you have the BALL DISEASE.