2. When you are unable to muster up the confidence to go speak to some one of the opposite sex.
Allen: I asked her to Marry me!
Jeff: WTF is wrong with you? Sounds like you have a pretty bad case of Ball Disease...
David: Man you should go talk to her, shes been giving you the fuck me eyes all night.
Tony: Well... I would, but...
David: Whats that? Oh thats right you have the BALL DISEASE.