Verb. Synonymous with discouraged, obliterated, or owned. Just as the video, "Two Girls, One Cup" destroys women's rights, any erection a man will ever have in the future, and the confidence of a proud toilet.
1. Samuel Jackson two girls one cups everyone else in every movie he's ever played in.
2. Renee Zelwegger's appearance totally two girls one cupped my burgeoning erection