Shrewd, or having incredible common sense, also
just being an overall smart-ass/quick wit.
Man 1- "Hey, man, did you see that bitch?"
Man 2- "That one?"
Man 1- "Yea, I was like 'let's go back to my place' and she looked at me and said 'no way, I only do good-looking guys.'"
Man 2- "Jeese, that's rough. What a sagacious slut."