When your agoraphobia is so severe that you can navigate your way around easier in GTA than the city you live in irl
Mark: "Hey, I'm catching a flight on saturday, do you think you could take me to the airport?"
Carl: "Sorry man, I've never been that far from home. I could've taken you if we were living in Las Venturas."
Mark: "That's a game..."
Carl: "Yeah.... but my Grand Theft Agoraphobia you know..."