Another way to say "chill out", "leave me alone", or "get off my ass."
Gets great response, causes the person who's on your ass to shut the hell up and back down.
Mom: Gonzo, did you do your homework yet?
Gonzo: Ma, hop of my nuts.
Mom: Yes master.
Fatass in car behind me: (Honking) Hey asshole, get off the road!
Gonzo: What the hell am I supposed to do? The jackoff in front of me is going slow, so hop off my nuts.
Fatass: Oh, sorry. I'm fat and stupid.