the illness that causes seemingly normal girls burst out in inconsolable tears for unfathomable reasons. At least one girl in every circle of friends is stricken by this disease. They are commonly found at frat parties, bars, and especially weddings.
Bro 1: Bro can you introduce to that girl?
Bro 2: Naw dude she has Crying Drunk Chick Syndrome you don't want to be stuck with her when that time bomb goes off.
Bro 1: what about her?
Bro 2: she's got the clap Bro 1: I am going in