The process of cutting someone's genitals off and throwing them out of a window.
A combination of the words castrate and defenestrate.
"Did you hear about David?! He got castrenestrated!"
"Wait... What the hell does that mean?"
"It means somebody cut off his balls and threw them out of a window"
"WHAT THE FUCK? Dude, seriously, why the FUCK are you telling me this?"