Verb; to handle a situation, mostly negative situations, in the most efficient, graceful and ruthlessly badass way possible to ensure the best outcome for oneself and the worst outcome for one's enemies. Slang: to treat women like disposable objects for sexual pleasure.
"You're going to drop me, Lucky Strike? That's fine, I'll just Don Draper your ass with a full page add in the paper."
"That Megan secretary is so hot, I'mma Don Draper THAT!"