Can be used in contexts of being shady, wack, stupid, retarded, or not making any sense at all...but mostly, shady.
Philippe: "This bitch is spice"
Spork Daddy: "Should we merk her?"
Matt: "Ya son, what's good?"
Philippe: "This bitch is gonna get me sent to prison, I know she's snitchin"
Jake: "I knew that bitch was spice, son"