Refers to traveling out of your way to intentionally come into contact with gorgeous members of the opposite sex.
Can be done by foot, but is preferably done in an expensive and flashy vehicle. The path traveled usually takes one by a certain locale where said hotties are known to congregate. Can also refer to following a particularly sexy person for a short time, or dawdling near them.
Guy 1: "Hey man, sorry I'm late. I ran a hot route in my bother's new car on the way over here."
Guy 2: "No problem dude. See any fine looking women?"