Includes various meanings:
1) Hemroids in your ass.
2) Steroids and people who stupidly use them
3) In racist cities, like Sarasota, FL -- refers to African-American people in a deragatory sense
1) My ass hurts so bad! I think my roids are blowin up again!
2) I want bigger muscles... I think I'll whip out my roids
3) Get outta here you ROID!