Getting extremely inebriated, to the point of incoherent mumbling downtowned
Micheal tried to tell us he had to go to the bathroom, but he was so tonied, we couldn't understand him, so he pissed himself.
getting so drunk that one pukes till blood vessels burst in one's eyes
Anthony got so tonied last night that he woke up with scabs on his eyes and vomit in his shower.
Getting extremely inebriated, to the point where one is very friendly to the opposite sex (usually used in reference to a female) tonied
Julie was so downtowned last night; she was dancing with every guy in the club.