A girl who is tainted is one who is extremely skanky. She is known for going from guy to guy and hooking up with them. She is tainted because it is unknown whether or not she has a STD.
A guy is tainted when he has sex with a girl who is tainted.
Person 1: You didnt hear about amanda? she hooked up with chris, adam, mike, and jamaal in the same night.
Person 2: Damn, she's tainted.
Person 1: Mike just had sex with melanie.
Person 2: Suck for him, he's tainted now
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