1 definition by Bubble101
A town in South Mississippi (40 miles from New Orleans/25 miles from the coast) that is known for its teen pregnancy, teen drug use and high school dropouts. At one time or another it was and may still be the highest rates in the nation. Oxycotin is also widely used here.
Afroman refers to Picayune in one of his songs.
Afroman refers to Picayune in one of his songs.
by Bubble101 August 16, 2006