1. A condition of having huge balls.
2. High levels of testosterone in either a male or female.
3. Willing to take a chance or a risk, not afraid to back down, but not putting ones nuts in harm.
1. "Bro Bill got huge balls!" "Yeah he got Huge Nut Syndrome (HNS)."
2."Damn that bitch is hella crazy, she just whooped that fools ass!" "Hell Ya I whooped his ass cuz i got Huge Nut Syndrome (HNS)!"
3. " I put my money on that homie he got Huge Nut Syndrome (HNS)."