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1 definition by Avast_Ye_Matey!!!

 
1.
The terrible affliction achieved by playing guitar hero for too many hours. Unfortunately, this disease usually takes hold when players are beginning to become one with their guitar and are achieving epic streaks. Your brain then decides to over think and your hand cant deal with the on coming information, the hand is no longer part of the equation and does what it feels like.
Also know as Guitar Hero Spaz Hand.
If you are unfortunate enough to get Guitar Hero Syndrome, any chance of 100% will definately go right out of the window.
by Avast_Ye_Matey!!! November 30, 2010
1 0