The only unattractive sister out of a large group of sisters. It is as if sexual attractiveness is a roll of dice and the unattractive sister was unfortunate enough to role two ones, hence the "Snake Eyes."
1. Shit, Kourtney and Kim Kardashian are so hot. Khloe is definitely the snake eyes of that litter.
2. Tyrone could have banged any one of Jerome's hot sisters, but he was so drunk he ended up with the snake eyes.