To completely dissolve one's thought process and abillity to be. Typically onset by a menber of the opposite sex. Devastating to brilliant minds.
In the movie Basic Instinct II, Sharon Stone completely mindfucks the supporting actor by setting events in motion that cause him to have a psychotic break and go on a killing rampage. Something that a Psychiatryst would never do.
"Dude, where am I?"
"You're in the back seat of my car, I found you huddled naked in some backwards mexican hotel cuddled in the corner whispering 'I am gonna be alright. I don't have 11 fingers. Barney is not some evil alien trying to kill me.' It was bad man."
"Damn, that bitch completely mindfucked me"
"Yeah, tell me about it"