(1) Most commonly used to mean a man who lays women like bricks.
(2) Justin Timberlake.
(3) What a jealous, jaded gay man wails indignantly at his partner when he discovers he's been getting some backdoor lovin' on the side.
(1) "That man ho actually thinks that crusty patch of skin on his dick is POISON IVY."
(2) "OH MY GOD! MAN HO IS PLAYING THE ASTRODOME TONIGHT!!!! OH MY GOD!!! *hyperventilates.* *has aneurysm.* *dies.*"
(3) "You tapped that douche bag bitch's ass! YOU MAN HO!!!!"