STD-Severe Testicular Distress. Usually occurs when humidity and temperature are very high.
Zane: "Damn dude, this hot ass weather has my balls all sweaty and uncomfortable."
Jesse: "Sounds like you got STD dude."
Zane: "What? How the hell would YOU know?"
Jesse: "Nah man, not A STD, but STD. Severe Testicular Distress."